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Structure‐based design and synthesis of pyrimidine containing reversible epidermal growth factor receptor (EGFR) inhibitors 1a–d are reported. The compounds (1a–d) inhibited the EGFR kinase activity in vitro with IC50 range 740 nm to 3 μm. mRNA expression of EGFR downstream target genes, that is twist, c‐fos and aurora were found to be altered upon treatment with compounds 1a–d. The compounds 1a–d...
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