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A high molecular weight hyaluronic acid-producing mutant, designated as Streptococcus equi KFCC 10830, was derived from Streptococcus equi ATCC 6580 by the serial selection programs after NTG treatment. The selected mutant had nonhemolytic, hyaluronidase-negative, kanamycin-resistant, and highly viscous characteristics. Various culture conditions were optimized in a 5-1 fermentor for the production...
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