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BACKGROUND:Neoadjuvant chemotherapy improves the survival of patients with high‐risk urothelial cancer. However, the lack of curative alternatives to cisplatin‐based chemotherapy is limiting for patients with neuropathy or hearing loss. Sequential chemotherapy also has not been well studied in the neoadjuvant setting. The authors explored sequential neoadjuvant ifosfamide‐based chemotherapy in a patient...
The PTEN gene, located on chromosome 10, is a phosphatase in the phosphatidylinositol 3′-kinase (PI3’K)-mediated signal transduction pathway. PTEN inhibits the activation of Akt, a serine-threonine kinase involved in proliferative metabolic and anti-apoptotic pathways, and has tumor suppressor properties. We used a PTEN adenoviral vector, Ad-MMAC, to assess the role of PTEN in the treatment of prostate...
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