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Epidemiological studies indicate that tobacco smoking can be protective against neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). The objective of the present study was to examine the changes in gene expression induced by chronic oral nicotine administration (100 μg/ml in 2% saccharin for 14 days), with special emphasis on amyloid precursor protein (APP) and...
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