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Parkinson’s disease (PD) is one of the most frequent neurodegenerative disease and represents a major therapeutic challenge because of the so far missing therapeutic means to influence the ongoing loss of dopaminergic innervation to the striatum. Cell replacement has raised hope to offer the first restorative treatment option. Clinical trials have provided “proof of principle” that transplantation...
The use of stem cells has been proven an attractive strategy for restoring lost cell or tissue functions. Stem cell therapy is nowadays routinely used in many clinical applications. The complexity of the tissue in the central nervous system however often limits the use of stem cells yet to reconstructions of defi ned wellknown neurotransmitter defi cits, for example the reconstitution of the nigro-striatal...
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