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Fragile X mental retardation syndrome is caused by the transcriptional silence of FMR1. Here, a quantitative PCR technique was used to examine the effect of Fmr1p on the expression of GABAA β subunits in different mouse brain regions. Our results demonstrated the reduction of GABAA β2 mRNA in all brain regions assessed, and the reduction of GABAA β3 mRNA in the cortex, suggesting that the expression...
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