Search results for: Michael Gelinsky

Items from 1 to 20 out of 69 results

article

Carbon screen‐printed electrodes modified with SiO₂‐CuO‐glucose oxidase film for toxicity assessment using bacteria as indicator systems

Marko Kuznetsov, Oksana Tananaiko, Michael Gelinsky, Max Witzleben, more

A portable voltammetric sensor for toxicity assessment was developed based on a screen‐printed carbon electrode modified with SiO₂‐CuO‐glucose oxidase (GOx) film. The method is based on the detection of the metabolic activity of E. coli towards glucose as an indicator systems in the presence of antiseptic drugs as model toxic compounds. CuO particles exhibited catalytic activity toward hydrogen peroxide...

article

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

Xiaopeng Yu, Hongshi Ma, Yufeng Wang, Jianxin Hao, more

Advanced Materials > 36 > 21 > n/a - n/a

The behavior of tissue resident cells can be influenced by the spatial arrangement of cellular interactions. Therefore, it is of significance to precisely control the spatial organization of various cells within multicellular constructs. It remains challenging to construct a versatile multicellular scaffold with ordered spatial organization of multiple cell types. Herein, a modular multicellular tissue...

article

Tailoring Materials for Modulation of Macrophage Fate

Jinhua Li, Xinquan Jiang, Hongjun Li, Michael Gelinsky, more

Advanced Materials > 33 > 12 > n/a - n/a

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity and adaptive immunity hold great promise for a broad range of prophylactic and therapeutic purposes. This review is focused on the design strategies and principles of immunomodulatory biomaterials from the standpoint of materials science to...

article

Black Bioceramics: Combining Regeneration with Therapy

Xiaocheng Wang, Jianmin Xue, Bing Ma, JinFu Wu, more

Advanced Materials > 32 > 48 > n/a - n/a

Bioceramics have been developed from bioinert to bioactive or biodegradable materials in the past few decades. However, at present, traditional bioceramics are still mainly used in bone tissue regeneration and dental restoration. In this work, a new generation of “black bioceramics,” extending the applications from tissue regeneration to disease therapy, is presented. Black bioceramics, through magnesium...

article

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

Henriette Bretschneider, Jan Mettelsiefen, Claudia Rentsch, Michael Gelinsky, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 3 > 1117 - 1128

For cementless total joint replacement implants, the biological response to physicochemical surface characteristics is crucial for their success that depends on fixation by newly formed bone. In this study, the surface of TiAl6V4 (Tilastan®) implants was modified by (a) corundum blasting, (b) corundum blasting followed by electrochemical calcium phosphate (CaP) deposition, and (c) titanium plasma...

article

Strontium enhances BMP‐2 mediated bone regeneration in a femoral murine bone defect model

Mandy Quade, Corina Vater, Saskia Schlootz, Julia Bolte, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 1 > 174 - 182

The application of strontium is one option for the clinical treatment of osteoporosis—a disease characterized by reduced bone density and quality—in order to reduce the risk of vertebral and nonvertebral fractures. Unlike other drugs used in osteoporosis therapy, strontium shows a dual effect on bone metabolism by attenuating cellular resorption and simultaneously enhancing new bone tissue formation...

article

Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approaches

Poh Soo Lee, Ricarda Hess, Jens Friedrichs, Vanessa Haenchen, more

Journal of Tissue Engineering and Regenerative Medicine > 13 > 9 > 1672 - 1684

Bone development and homeostasis are intricate processes that require co‐existence and dynamic interactions among multiple cell types. However, controlled dynamic niches that derive and support stable propagation of these cells from single stem cell source is not sustainable in conventional culturing vessels. In bioreactor cultures that support dynamic niches, the limited source and stability of growth...

article

Two‐step stem cell therapy improves bone regeneration compared to concentrated bone marrow therapy

Julia Bolte, Corina Vater, Anna Carla Culla, Tilman Ahlfeld, more

Journal of Orthopaedic Research® > 37 > 6 > 1318 - 1328

Adult stem cells are a promising tool to positively influence bone regeneration. Concentrated bone marrow therapy entails isolating osteoprogenitor cells during surgery with, however, only low cells yield. Two step stem cell therapy requires an additional harvesting procedure but generates high numbers of progenitor cells that facilitate osteogenic pre‐differentiation. To further improve bone regeneration,...

article

Investigating the effect of sterilisation methods on the physical properties and cytocompatibility of methyl cellulose used in combination with alginate for 3D-bioplotting of chondrocytes

Ella Hodder, Sarah Duin, David Kilian, Tilman Ahlfeld, more

Journal of Materials Science: Materials in Medicine > 2019 > 30 > 1 > 1-16

For both the incorporation of cells and future therapeutic applications the sterility of a biomaterial must be ensured. However, common sterilisation techniques are intense and often negatively impact on material physicochemical attributes, which can affect its suitability for tissue engineering and 3D printing. In the present study four sterilisation methods, autoclave, supercritical CO₂ (scCO₂)...

article

Functionalized Bioink with Optical Sensor Nanoparticles for O₂ Imaging in 3D‐Bioprinted Constructs

Erik Trampe, Klaus Koren, Ashwini Rahul Akkineni, Christian Senwitz, more

Advanced Functional Materials > 28 > 45 > n/a - n/a

Research on 3D bioprinting of living cells has strong focus on printable biocompatible materials and monitoring of cell growth in printed constructs, while cell metabolism is mostly measured in media surrounding the constructs or by destructive sample analyses. Bioprinting is combined with online imaging of O₂ by functionalizing a hydrogel bioink via addition of luminescent optical sensor nanoparticles...

article

Novel alginate biphasic scaffold for osteochondral regeneration: an in vivo evaluation in rabbit and sheep models

Giuseppe Filardo, Francesco Perdisa, Michael Gelinsky, Florian Despang, more

Journal of Materials Science: Materials in Medicine > 2018 > 29 > 6 > 1-13

Current therapeutic strategies for osteochondral restoration showed a limited regenerative potential. In fact, to promote the growth of articular cartilage and subchondral bone is a real challenge, due to the different functional and anatomical properties. To this purpose, alginate is a promising biomaterial for a scaffold-based approach, claiming optimal biocompatibility and good chondrogenic potential...

article

Non-functionalized soft alginate hydrogel promotes locomotor recovery after spinal cord injury in a rat hemimyelonectomy model

Kerim Hakan Sitoci-Ficici, Marina Matyash, Ortrud Uckermann, Roberta Galli, more

Acta Neurochirurgica > 2018 > 160 > 3 > 449-457

Background Spinal cord injury (SCI) and the consecutive devastating neurological sequelae have an enormous individual and economic impact. Implantation of functionalized hydrogels is a promising approach, because they can serve as a matrix for the regenerating tissue, carry and release bioactive molecules and various cell types. We already demonstrated that non-functionalized soft alginate hydrogel...

article

Novel chitin scaffolds derived from marine sponge Ianthella basta for tissue engineering approaches based on human mesenchymal stromal cells: Biocompatibility and cryopreservation

Vitalii V. Mutsenko, Oleksandr Gryshkov, Lothar Lauterboeck, Olena Rogulska, more

International Journal of Biological Macromolecules > 2017 > 104 > PB > 1955-1965

The extraordinary biocompatibility and mechanical properties of chitinous scaffolds from marine sponges endows these structures with unique properties that render them ideal for diverse biomedical applications. In the present work, a technological route to produce “ready-to-use” tissue-engineered products based on poriferan chitin is comprehensively investigated for the first time. Three key stages...

article

3D chitinous scaffolds derived from cultivated marine demosponge Aplysina aerophoba for tissue engineering approaches based on human mesenchymal stromal cells

Vitalii V. Mutsenko, Vasilii V. Bazhenov, Olena Rogulska, Dmitriy N. Tarusin, more

International Journal of Biological Macromolecules > 2017 > 104 > PB > 1966-1974

The recently discovered chitin-based scaffolds derived from poriferans have the necessary prosperities for potential use in tissue engineering. Among the various demosponges of the Verongida order, Aplysina aerophoba is an attractive target for more in-depth investigations, as it is a renewable source of unique 3D microporous chitinous scaffolds. We found these chitinous scaffolds were cytocompatible...

article

Additive Biotech—Chances, challenges, and recent applications of additive manufacturing technologies in biotechnology

Felix Krujatz, Anja Lode, Julia Seidel, Thomas Bley, more

New Biotechnology > 2017 > 39 > PB > 222-231

The diversity and complexity of biotechnological applications are constantly increasing, with ever expanding ranges of production hosts, cultivation conditions and measurement tasks. Consequently, many analytical and cultivation systems for biotechnology and bioprocess engineering, such as microfluidic devices or bioreactors, are tailor-made to precisely satisfy the requirements of specific measurements...

article

Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells

Anastasia Gabrielyan, Elena Neumann, Michael Gelinsky, Angela Rösen-Wolff

Stem Cell Research & Therapy > 2017 > 8 > 1 > 1-10

Background The main goal of bone tissue engineering has been the generation of healthy bone in order to replace affected tissue. Therefore, optimized biomaterials are needed which allow the survival and growth of mesenchymal stem cells. Until now the key challenge in the clinical application of cell-based tissue engineering bone implants was poor diffusion of oxygen into the tissue, making functional...

article

Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bone

Marcus Rohnke, Stefanie Pfitzenreuter, Boris Mogwitz, Anja Henß, more

Journal of Controlled Release > 2017 > 262 > C > 159-169

Drug functionalization of biomaterials is a modern and popular approach in biomaterials research. Amongst others this concept is used for the functionalization of bone implants to locally stimulate the bone healing process. For example strontium ions (Sr²⁺) are administered in osteoporosis therapy to stimulate bone growth and have recently been integrated into bone cements. Based on results of different...

article

Intrinsic 3D Prestressing: A New Route for Increasing Strength and Improving Toughness of Hybrid Inorganic Biocements

Martha Schamel, Jake E. Barralet, Michael Gelinsky, Jürgen Groll, more

Advanced Materials > 29 > 35 > n/a - n/a

Cement is the most consumed resource and is the most widely used material globally. The ability to extrinsically prestress cementitious materials with tendons usually made from steel allows the creation of high‐strength bridges and floors from this otherwise brittle material. Here, a dual setting cement system based on the combination of hydraulic cement powder with an aqueous silk fibroin solution...

article

Data on TOF-SIMS analysis of Cu2+, Co2+ and Cr3+ doped calcium phosphate cements

Anja Henß, Martha Schamel, Uwe Gbureck, Michael Gelinsky, more

Data in Brief > 2017 > 13 > C > 353-355

This article contains data of time of flight secondary ion mass spectrometry (TOF-SIMS) analysis of brushite-forming calcium phosphate cements doped with biologically active metal ions. This data are related to the research article “Cu²⁺, Co²⁺ and Cr³⁺ doping of a calcium phosphate cement influences materials properties and response of human mesenchymal stromal cells” (Schamel et al., 2017) [1]. Cu...

article

Three‐dimensional plotting of a cell‐laden alginate/methylcellulose blend: towards biofabrication of tissue engineering constructs with clinically relevant dimensions

Kathleen Schütz, Anna‐Maria Placht, Birgit Paul, Sophie Brüggemeier, more

Journal of Tissue Engineering and Regenerative Medicine > 11 > 5 > 1574 - 1587

Biofabrication of tissue engineering constructs with tailored architecture and organized cell placement using rapid prototyping technologies is a major research focus in the field of regenerative therapies. This study describes a novel alginate‐based material suitable for both cell embedding and fabrication of three‐dimensional (3D) structures with predefined geometry by 3D plotting. The favourable...

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INFONA - science communication portal

Search results for: Michael Gelinsky

Carbon screen‐printed electrodes modified with SiO₂‐CuO‐glucose oxidase film for toxicity assessment using bacteria as indicator systems

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

Tailoring Materials for Modulation of Macrophage Fate

Black Bioceramics: Combining Regeneration with Therapy

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

Strontium enhances BMP‐2 mediated bone regeneration in a femoral murine bone defect model

Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approaches

Two‐step stem cell therapy improves bone regeneration compared to concentrated bone marrow therapy

Investigating the effect of sterilisation methods on the physical properties and cytocompatibility of methyl cellulose used in combination with alginate for 3D-bioplotting of chondrocytes

Functionalized Bioink with Optical Sensor Nanoparticles for O₂ Imaging in 3D‐Bioprinted Constructs

Novel alginate biphasic scaffold for osteochondral regeneration: an in vivo evaluation in rabbit and sheep models

Non-functionalized soft alginate hydrogel promotes locomotor recovery after spinal cord injury in a rat hemimyelonectomy model

Novel chitin scaffolds derived from marine sponge Ianthella basta for tissue engineering approaches based on human mesenchymal stromal cells: Biocompatibility and cryopreservation

3D chitinous scaffolds derived from cultivated marine demosponge Aplysina aerophoba for tissue engineering approaches based on human mesenchymal stromal cells

Additive Biotech—Chances, challenges, and recent applications of additive manufacturing technologies in biotechnology

Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells

Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bone

Intrinsic 3D Prestressing: A New Route for Increasing Strength and Improving Toughness of Hybrid Inorganic Biocements

Data on TOF-SIMS analysis of Cu2+, Co2+ and Cr3+ doped calcium phosphate cements

Three‐dimensional plotting of a cell‐laden alginate/methylcellulose blend: towards biofabrication of tissue engineering constructs with clinically relevant dimensions

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