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Hereditäre Amyloidosen stellen eine klinisch und genetisch heterogene Gruppe autosomal-dominant vererbter Erkrankungen dar. Sie werden durch Mutationen physiologischer Proteine verursacht; in den meisten Fällen handelt es sich um Transthyretin (TTR)-Amyloidosen. Die Art der Mutation bestimmt den Verlauf, die vorwiegend betroffenen Organe sowie den Altersgipfel der Erkrankung. Die Lebenszeit wird meist...
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