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In this work, we use particle swarm optimization (PSO) to adjust the parameters of a membrane computing (MC) model of a synthetic autoinducer-2 (AI-2) signalling system in genetically engineered Escherichia coli bacteria. Bacteria release, receive and recognize signalling molecules in order to exchange information. These signalling molecules are responsible for coordinating gene expression at the...
Random Boolean networks (RBNs) are abstract models of gene regulatory networks that govern gene expression in cells. We have developed an evolutionary model to explore the dynamic states of random Boolean networks using heuristic optimization methods. The generic behavior of random Boolean networks is investigated as the evolutionary process works its way through different generations, identifying...
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