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Bisphosphonates are the mainstay of treatment for postmenopausal osteoporosis. Their efficacy and safety have been assessed in animal models of osteoporosis, from which effects of treatment on bone mass, remodeling and strength can be measured. For example, the nitrogen-containing bisphosphonate, ibandronate, has been assessed in intact, ovariectomized (OVX) and ovariohysterectomized rats, dogs and...
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