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Brain injury generates the release of a multitude of factors including extracellular nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions in the acute phase and also protective and reparative actions in the later recovery phase to allow neuroregeneration. A promising strategy toward restoration of neuronal function is based on activation of endogenous adult...
The aim of this study was to see whether the compound adenosine 5'-tetraphosphate (Ap 4 ) is active in the central nervous system by examining its effect on isolated rat brain synaptic terminals. Ap 4 proved to be more resistant to ecto-enzymatic hydrolysis than adenosine triphosphate (ATP), showing only 2% hydrolysis after a 2-min incubation, compared to 75% for ATP.In addition, Ap...
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