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Whole‐slide scanners allow the digitization of an entire histological slide at very high resolution. This new acquisition technique opens a wide range of possibilities for addressing challenging image analysis problems, including the identification of tissue‐based biomarkers. In this study, we use whole‐slide scanner technology for imaging the proliferating activity patterns in tumor slides based...
Glioblastomas are very aggressive cerebral tumors which are characterized by strong proliferative activity which is often assessed using the Ki-67 staining method. We propose a novel clustering method that exhibits high performance to detect Ki-67 hot-spots on immunohistochemical slides of glioblastomas.
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