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This study was designed to investigate the functional roles of histamine and histamine H1-receptor agonist and antagonist in the development of liver function impairment in immunized rabbits. The study comprised of six groups containing 18 rabbits each. Group III–VI received histamine (100μg/kg, s.c.), H1R-agonist (HTMT, 10μg/kg, s.c.), H1R-antagonist (pheniramine, 10mg/kg, i.m.), and H1R-antagonist...
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