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Nanofluidics
In article number 2102150, Hui Yang and co‐workers report a high‐throughput nanofluidic device for loading of various cargos into exosomes. The exosomes treated by the device can deliver their drug cargos to cancer cells and induce cell death, indicating the potential opportunities of the device for developing new exosome‐based delivery vehicles for further biomedical applications.
Efficient loading of various exogenous cargos into exosomes while not affecting their integrity and functionalities remains a major challenge. Here, a nanofluidic device named “exosome nanoporator (ENP)” is presented for high‐throughput loading of various cargos into exosomes. By transporting exosomes through nanochannels with height comparable to their dimension, exosome membranes are permeabilized...
Sweat excretion is a dynamic physiological process that varies with body position, activity level, environmental factors, and health status. Conventional means for measuring the properties of sweat yield accurate results but their requirements for sampling and analytics do not allow for use in the field. Emerging wearable devices offer significant advantages over existing approaches, but each has...
This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin‐mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well‐defined sequence...
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