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The lupane‐type triterpenoids are endowed with a wide range of biological activities such as antiviral, anti‐inflammatory and anticancer activity. We describe here its potential application in Alzheimer's disease (AD) treatment as an inhibitor of PS1/BACE1 interaction. 3‐α‐Akebonoic acid, which emanated from a high throughput screening (HTS), was discovered to interfere with PS1/BACE1 interaction...
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