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Bacteria‐induced epidemics and infectious diseases are seriously threatening the health of people around the world. In addition, antibiotic therapy has been inducing increasingly more serious bacterial resistance, which makes it urgent to develop new treatment strategies to combat bacteria, including multidrug‐resistant bacteria. Natural extracts displaying antibacterial activity and good biocompatibility...
Cavitation Ablation
In article number 2302744, Zhe Wu, Lang Ma, Qiang Lu, and co‐workers develop an Mn‐coordinated polyphthalocyanine sonocavitation agent that consists of Mn‐phthalocyanine as the catalytic sites and the conjugated layer‐stacked polyphthalocyanine network as the acoustic response group, which will help deepen the understanding of non‐thermal cavitation ablation histotripsy and the...
Non‐invasive cancer treatment strategies that enable local non‐thermal ablation, hypoxia relief, and reactive oxygen species (ROS) production to achieve transiently destroying tumor tissue and long‐term killing tumor cells would greatly facilitate their clinical applications. However, continuously generating oxygen cavitation nuclei, reducing the transient cavitation sound intensity threshold, relieving...
Drug‐coated balloons (DCB) intervention is an important approach for the treatment of atherosclerosis (AS). However, this therapeutic approach has the drawbacks of poor drug retention and penetration at the lesion site. Here, a lipophilic drug‐loaded nanomotor as a modified balloon coating for the treatment of AS is reported. First, a lipophilic nanomotor PMA‐TPP/PTX loaded with drug PTX and lipophilic...
Nanovaccine‐based immunotherapy (NBI) has the ability to initiate dendritic cell (DC)‐mediated tumor‐specific immune responses and maintain long‐term antitumor immune memory. To date, the mechanism by which the mechanical properties of nanoparticles alter the functions of DCs in NBI remains largely unclear. Here, a soft mesoporous organosilica‐based nanovaccine (SMONV) is prepared and the elasticity‐dependent...
Elastic Nanovaccines
In article number 2201108, Zhaogang Teng, Heng Dong, Yongbin Mou, and co‐workers report a soft mesoporous organosilica‐based nanovaccine (SMONV) and demonstrate that elastic SMONV evokes robust antitumor immune cascades, including lymphatic drainage, antigen internalization and cross‐presentation, and tumor‐specific T‐cell immune responses. Treg‐mediated immunosuppression is inhibited...