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Prenatal cocaine exposure is associated with abnormal arousal and attention in children. Since methylphenidate (MPD) is widely used to treat attention disorders, we wanted to determine whether prenatal cocaine exposure affects brain function in response to MPD as measured by glucose metabolism in a rodent model. Pregnant rats received 60mg/kg cocaine or vehicle from gestational days 8–22 by intragastric...
Rationale Previous studies have shown that the expression of behavioral sensitization to psychostimulants depends on the age and gender of the animal. Objective This study was conducted to determine the pattern of behavioral sensitization to repeated administration of methylphenidate (MPD) at three different developmental ages and to assess the response to a cocaine challenge in adulthood. Methods...
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