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We propose to exhibit a live demonstration of a CMOS multi-modality cellular biosensor array chip that can facilitate drug screening and cell-based assays. The multi-modality sensing functionality enables real-time measurements of multiple physiological parameters of biological cells and cell clusters, such as their electric potential, impedance, optical opacity, and bioluminescent imaging. Compared...
In this paper, we present a fully integrated multi-modality CMOS cellular sensor array with four sensing modalities to characterize different cell physiological responses, including extracellular voltage recording, cellular impedance mapping, optical detection with shadow imaging and bioluminescence sensing, and thermal monitoring. The sensor array consists of nine parallel pixel groups and nine corresponding...
Cell-based assays are powerful tools to characterize cell- or tissue-specific physiological behaviors under external biochemical stimuli. External biochemical stimuli trigger endogenous cellular mechanisms that produce a cascade of physiological changes, resulting in easily measurable signals [1, 2]. Cell-based assays are widely used for large-scale drug screening in the pharmaceutical industry, where...
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