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The Prep1 homeodomain transcription factor is essential for embryonic development. 25% of hypomorphic Prep1 i/i embryos, expressing the gene at 2% of the normal levels, survive pregnancy and live a normal-length life. Later in life, however, these mice develop spontaneous pre-tumoral lesions or solid tumors (lymphomas and carcinomas). In addition, transplantation of E14.5 fetal liver (FL)...
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