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Aberrant serum N‐glycan profiles have been observed in multiple cancers including non‐small‐cell lung cancer (NSCLC), yet the potential of N‐glycans in the early diagnosis of NSCLC remains to be determined. In this study, serum N‐glycan profiles of 275 NSCLC patients and 309 healthy controls were characterized by MALDI‐TOF‐MS. The levels of serum N‐glycans and N‐glycosylation patterns were compared...