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Purpose
To evaluate the utility of hyperpolarized [1‐13C]‐l‐lactate to detect hepatic pyruvate carboxylase activity in vivo under fed and fasted conditions.
Methods
[1‐13C]‐labeled sodium L‐lactate was polarized using a dynamic nuclear polarizer. Polarization level and the T1 were measured in vitro in a 3 Telsa MR scanner. Two groups of healthy rats (fasted vs. fed) were prepared for in vivo studies...
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