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SummaryThe contractile function of the heart requires the release of Ca2+ from intracellular Ca2+ stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of Ca2+ release depends on the amount of Ca2+ loaded into the Ca2+ store and the way in which this ‘Ca2+ load’ influences the activity of the cardiac ryanodine receptor Ca2+ release channel (RyR2).The effects of the Ca2+ load...
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