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Critical‐sized bone defects are incapable of self‐healing and are commonly seen in clinical practice. The authors explore a new treatment for this, decellularized periosteum is applied to chitosan globules (chitosan‐DP globules) as a hybrid material. The efficacy of chitosan‐DP globules on rabbit femoral condyle bone defects is assessed with biocompatibility, biomechanics, and osteogenic efficiency...
A series of amphiphilic multi‐armed PPn copolymers were prepared by ROP of Phe‐NCA with PEI‐25k as a macroinitiator. The particle size of the PPn/DNA complexes was about 100 nm and the zeta potentials were below 20 mV. An MTT assay demonstrated that all the PPn copolymers had lower cytotoxicity compared to PEI‐25k. In vitro gene transfection studies were also conducted in HeLa, 293 and CT 26 cells...
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