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Direct reconstruction algorithms for PET are capable of producing lower variance parametric images than those from the traditional frame-based approach. However, if the selected kinetic model is not appropriate for all voxels in the field-of-view, structured residuals from poor model fits can propagate bias into neighboring regions where the model is accurate. We previously proposed a direct reconstruction...
Respiratory motion degrades PET image quality and is unavoidable. Respiratory gating and/or motion correction are usually performed to reduce the effect of respiratory motion. However, these methods generally require motion information from external devices. Several groups have proposed data-driven motion extraction methods by analyzing variation of counts, or center-of-mass in reconstructed dynamic...
The aim of this research is to extend a direct parametric reconstruction algorithm for dynamic PET to include spillover terms for use in cardiac perfusion imaging. Perfusion imaging with cardiac PET is used clinically to produce images of myocardial blood flow, aiding the diagnosis of coronary artery disease and the monitoring of condition of coronary circulation in response to treatment. PMOLAR-1T,...
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