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DNA-assisted assembly has been demonstrated as a powerful method for synthesizing plasmonic nanostructures possessing electromagnetic hot spots for surface-enhanced Raman spectroscopy (SERS). In this work, we use DNA molecules as linkers to synthesize core-satellite nanostructures for SERS molecular detection. The interparticle distance, which is critical to Raman enhancement, is fine-tuned by growing...
PCR is an important biosensing method since it can amplify DNA by many orders of magnitude. However, for food safety and environmental monitoring, the target molecule is usually not DNA. Here we demonstrate a detection method that integrates competitive assay format, magnetic bead separation, and isothermal DNA amplification for sensitive detection of tetracycline (TET) and other molecules. While...
We use thermophoresis to accumulate and quantify biomolecules under a laser-induced temperature gradient. As biomolecules accumulate at the heated region, the concentration of the molecules can be determined based on the level of accumulation.
Scanning tunneling microscopy (STM) lithography was utilized to investigate a 12-mer HS-ssDNA self-assembled Au (111) surface. Under low sample bias and high tunneling current, the repeated scanning resulted in the growth of nanostripes. The stripe orientation, the stripe width, and the spacer width between adjacent nanostripes were found to be dependent on their relative locations from dislocation...
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