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Objective: The present work is aimed at elucidating the signalling pathway(s) triggered by activation of A 2A receptors involved in the facilitation of noradrenaline release in rat tail artery as an attempt to clarify their role in the cardiovascular system. Methods: Electrically evoked (5 Hz, 100 pulses, 1 ms) tritium overflow was evaluated in preparations of rat tail artery, pre-incubated...
In the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 μM), but not the A 2A agonist CGS 21680 (0.001-10 μM), caused a facilitation of electrically evoked noradrenaline release (up to 43+/-4%), when inhibitory adenosine A 1 receptors were blocked.NECA-elicited facilitation of noradrenaline release was prevented by the A 2 ...
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