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Previously, we have reported alterations to HSP27 during Microcystin‐LR (MC‐LR)‐induced cytoskeletal reorganization in the human liver cell line HL7702. To further elucidate the detailed mechanism of MC‐LR‐induced cytoskeletal assembly, we focused on two cytoskeletal‐related proteins, Tau and VASP. These two proteins phosphorylated status influences their ability to bind and stabilize cytoskeleton...
Microcystin‐LR (MC‐LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC‐LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702 cells (a human normal liver cell line) were incubated in MC‐LR for 24 h. The existence...
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