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Periodontitis is the major cause of tooth loss in adults and is mainly characterized by alveolar bone destruction. Elucidating the mesenchymal stem cell (MSC)/progenitor populations of alveolar bone formation will provide valuable insights into regenerative approaches to clinical practice, such as endogenous regeneration and stem‐cell‐based tissue engineering therapies. Classically, MSCs residing...
Objectives
In this study, we used the mouse incisor model to investigate the regulatory mechanisms of Wnt/β‐catenin signaling on Axin2+ cells in tooth development.
Materials and Methods
Axin2lacZ/+ reporter mice were used to define the expression pattern of Axin2 in mouse incisors. We traced the fate of Axin2+ cells from postnatal Day 21 (P21) to P56 using Axin2CreERT2/+ and R26RtdTomato/+ reporter...