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Ever growing “omics” data and continuously accumulated biological knowledge provide an unprecedented opportunity to identify molecular biomarkers and their interactions that are responsible for cancer phenotypes that can be accurately defined by clinical measurements such as in vivo imaging. Since signaling or regulatory networks are dynamic and context-specific, systematic efforts to characterize...
In protein subcellular localization prediction, a predominant scenario is that the number of available features is much larger than the number of data samples. Among the large number of features, many of them may contain redundant or irrelevant information, causing the prediction systems suffer from overfitting. To address this problem, this paper proposes a dimensionality-reduction method that applies...
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