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A fused pH and fluorescence sensor is proposed, and a prototype has been fabricated using CMOS silicon integrated circuit technology. Fluorescence intensity and pH can be detected at the same pixel for the first time. In the proposed device, a pH sensor which uses CCD image sensor technology and a filter-less fluorescence detection sensor are fused in the same pixel, enabling fluorescence and pH signals...
A multi-modal sensor, with which was possible to simultaneously measure pH, electrical conductivity (EC) and temperature, was fabricated. The pH sensor, EC sensor, and temperature sensor were integrated using compatible complementary metal-oxide semiconductor (CMOS) logic technology on a small Si chip (area, 25 mm2). Simultaneous measurements of pH, EC and temperature were demonstrated, and the sensor...
32times32 acetylcholine image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of acetylcholine distribution was carried out without label and a huge measurement. Acetylcholine imaging technology has a lot of potential for the early stage of Alzheimer's disease, the release mechanism between terminal neurons. In addition, the proposed sensor...
Silicon smart microchips with CMOS/MEMS technology are realized for intelligent sensing. In our developed chips, tow new type sensor chips are presented here. One is Si microprobe electrode array for using in the recording of neurons in the tissue. The probe array can be fabricated on IC chip, using standard IC process followed by a selective Si probe growth. Another one is pH image sensors successfully...
32 x 32 pH image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of a chemical reaction and pH distribution was carried out for the first time. The pH variations by a chemical reaction are observed by 200 ms step (i.e. 5 flames per sec). The pH image sensor was able to take a pH image of mouse stomach successfully. It means that the novel image...
We successfully fabricated a super high sensitivity charge transfer type pH sensor. The proposed pH sensor is possible to amplify the sensing signals without an external amplifier by accumulation cycle. The pH sensitivity was obtained 5048 mV/pH, which is approximately 100 times higher than the Ion Sensitive Field Effect Transistor (ISFET), which is the most familiar pH sensor using semiconductor...
We present about a pH sensor, which is capable of measuring high sensitivity using charge transfer technique. The sensitivity of pH was obtained 1130 mV/pH by charge accumulation operation. The proposed pH sensor using charge transfer technique is possible to increase a sensing signal without an extra amplifier. It is expected that charge transfer type pH sensor increases sensitivity and decreases...
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