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This paper describes the design and construct of a fully biocompatible, microfluidic, dielectric sensor targeted at monitoring human whole blood coagulation at the point-of-care (POC). The sensor assembly procedure involves using sputtered electrodes in a microfluidic channel with a physiologically relevant height of 50μm to create a three-dimensional (3D), parallel-plate, capacitive sensing area...
Dielectric spectroscopy (DS) is a powerful monitoring technique that can extract important molecular and cellular properties from a variety of biological materials. DS measurements on human whole blood can reveal a wealth of physiologic information, primarily from the dispersion region that arises from interfacial polarization of red blood cells (RBCs) [1]. Specifically, the use of DS to monitor the...
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