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The main challenge of bioluminescence tomography (BLT) is the ill-posed, non-unique nature of the inverse problem. To get reliable reconstruction, permissible source region is a commonly used a priori knowledge in the inverse procedure. In this paper, to accurately reveal 3D distribution of bioluminescent sources from limited boundary measurement, we propose an iterative reconstruction method incorporating...
Bioluminescence tomography (BLT) is a promising molecular imaging tool that may play an important role in preclinical research. However, the accurate and stable reconstruction of interior targets remains a challenge for wide application of this imaging modality. We present a novel reconstruction scheme to improve the BLT result by using the simplified spherical harmonics approximation model and homotopy...
Bioluminescence Tomography (BLT) reconstruction is a highly ill-posed inverse problem. In this research, we formulate it as a quadratically constrained least squares problem and present a trust region method for solving this problem. Simulations based on a heterogeneous phantom demonstrate that the trust region method has the capability to effectively handle the ill-posedness of BLT. The experiments...
Bioluminescence tomography is a new modality of optical molecular imaging for localizing and quantifying bioluminescence source in a small living animal. The reconstruction of internal bioluminescent source is still a difficult problem. In this paper, a trial and error approach based on Monte Carlo method is developed for localizing the bioluminescent source. The iteration number of the trial and...
Reconstruction of the bioluminescent source information in small animals in vivo is the inverse problem of Bioluminescence tomography (BLT), which is proved severely ill-posed. Regularization plays an important role in BLT, and choosing the right amount of regularization is crucial to get a meaningful result. However, automated methods to choose a regularization parameter have not been sufficiently...
Bioluminescence tomography (BLT) is an inherent ill-posed inverse problem to reconstruct the internal source in 3-D with limited measurements on the external surface. In most BLT studies so far, a relatively small permissible source region or multispectral approach is typically used to enhance the stability or quality of the solution. In this letter, considering the sparsity characteristic of the...
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