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Acid-base balance is the very important part of human homeostasis. Alteration in tissue pH can be an indicator of many diseases, such as tumor. Amide proton transfer imaging, a novel technique based on magnetization transfer and chemical exchange, was proved to be relying on pH to a great extent, in which proton transfer between endogenous proteins and peptides and tissue water. To the present APT...
When cerebral nervous tissue lacks of blood and oxygen, neurocyte is altered in metabolism, following with intracellular acid-base disturbance. Alteration of intracellular pH value can influence the magnetization transfer ratio (MTR). So pH-sensitive magnetization transfer imaging can reflect the alteration in metabolism. Using this technology to image ischemic brain may make an early detection and...
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