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Experimental studies revealed spatial navigation impairments in schizophrenic patients. Both human and animal subjects exhibited diminished navigation performances compared to control ones. In brain, hippocampus is believed to be more involved in navigation and memory. In the pathology of schizophrenia, neural mechanisms especially synaptic transmission of hippocampal neurons change and functionalities...
In this work we propose a biophysical neural network model to investigate some of the impacts of the Alzheimer's disease (AD) on spatial navigation in a simulated rodent. The model is a hybrid model developed based on physiological and functional description of neuronal networks in the hippocampus engaged in place field formation. The model of hippocampal network takes into account both anatomical...
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