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Gene circuits are a functional innovation in synthetic biology for engineering cellular behavior. Recent advances have demonstrated that gene circuits can be exploited for dynamically controlling pathway redirection and pathway balance to produce valuable chemicals. The next frontier is to engineer robust, sensitive, and efficient circuits that adapt to changing conditions.
Redox balance plays an important role in the production of enzymes, pharmaceuticals, and chemicals. To meet the demands of industrial production, it is desirable that microbes maintain a maximal carbon flux towards target metabolites with no fluctuations in redox. This requires functional cofactor systems that support dynamic homeostasis between different redox states or functional stability in a...
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