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Drug repurposing of non-antimicrobials is a novel method to augment a seriously depleted drug pipeline for targeting drug–resistant pathogens. This article highlights the potent antimicrobial activity of Ivacaftor against Staphylococcus aureus, including vancomycin– and other multidrug–resistant strains. The potent activity of Ivacaftor in vivo is also demonstrated in a murine neutropenic thigh infection...
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