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Previously we have reported that RT4, a well differentiated human bladder cancer line, increases the expression of macrophage derived chemokine (MDC) and interferon (IFN)-γ-inducible protein-10 (IP-10) in response to IFN-γ and tumor necrosis factor (TNF)-α. In this study we examined the signal mechanisms for inducting these 2 chemokines in RT4 cells by lipopolysaccharide (LPS), IFN-γ and TNF-α. ...
Successful bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer is associated with proper induction of T helper (Th)1 immunity. Unfortunately, 30% to 40% of bladder tumors never respond to BCG. We sought evidence of antagonistic Th2 chemokine production by bladder tumors as a potential cause of BCG nonresponsiveness. Expression of interferon-γ inducible protein-10 (IP-10), a Th1 chemokine,...
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