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Microbubbles (MBs) on the order of 1 – 5 microns have the ability to circulate in the vascular space with sufficient scattering ability to be used as ultrasound contrast and molecular imaging agents. However, for the purposes of extravascular ultrasound imaging, MBs are too large to pass through the endothelial gap junctions of leaky tumor vasculature. Bubbles on the order of 100s of nanometers may...
Most gas-filled ultrasound contrast agents are produced range of several microns in diameter, which limits them to flow within intravascular space. One mechanism proposed to produce extravascular imaging agents is acoustic droplet vaporization. Liquid perfluorocarbon droplets can be manufactured in the sub-micron range and can then passively diffuse through leaky tumor vasculature. It is hypothesized...
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