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The receptor interacting protein kinase 1 (RIP1) is essential for the activation of nuclear factor κB (NF-κB) by tumor necrosis factor α (TNFα). Here, we present evidence that TNFα induces the polyubiquitination of RIP1 at Lys-377 and that this polyubiquitination is required for the activation of IκB kinase (IKK) and NF-κB. A point mutation of RIP1 at Lys-377 (K377R) abolishes its polyubiquitination...
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