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Microbial infections and microbial resistance lead to a high demand for new antimicrobial agents. Quaternized polysaccharides are cationic antimicrobial candidates; however, the limitation of homogeneous synthesis solvents that affect the molecular structure and biological activities, as well as their drug resistance remains unclear. Therefore, the authors homogeneously synthesize a series of quaternized...
Antibiotic Resistance
In article number 2104885, Runhui Liu, Wei Jiang, Jie Cai, and co‐workers construct quaternized polysaccharide‐based cationic micelles with outstanding biocompatibility, excellent broad‐spectrum antimicrobial ability and low propensity for resistance, effective inhibition and eradication of mature bacterial biofilms, and that accelerate MRSA‐infected biofilms wound healing, which...
Water-soluble and white quaternized chitin (QC) was homogeneously synthesized by stirring transparent chitin solution (2%) in 8wt%NaOH/4wt% urea aqueous solution containing 2,3-Epoxypropyltrimethylammonium Chloride (EPTMAC) at 10°C for 24h. The structure and properties of quaternized chitin were characterized by FT-IR, XRD, 1 H NMR, GPC, element analysis and ζ-potential. The results indicate...
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