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Wide-field fluorescence lifetime imaging allows for fast imaging of large sample at the cost of limited sensitivity to weak fluorescence signals. To overcome this limitation, we develop an active illumination strategy that optimizes the spatial parameters of the illumination in order to acquire optimal wide-field fluorescence signals even in the presence of large fluorophore concentration distributions...
Fluorescence lifetime imaging is a commonly-used molecular imaging technique for preclinical and clinical studies of cells or tissues. Herein, the accuracy of lifetime imaging in the case of a bi-exponential model is investigated based on limited time data points. An in silico investigation shows that estimation accuracy of the model parameters involved (lifetimes and fractional amplitudes) can be...
One of the key challenges in anti-cancer drug validation is to quantitatively discriminate in vivo non-specific receptor-independent tumor accumulation from receptor-mediated uptake into the tumor cells. To overcome this challenge, we develop a new near-infrared Förster resonance energy transfer fluorescence lifetime imaging (NIR FRET FLIM) technique. We apply herein this novel approach to monitor...
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