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Myopia is a growing concern in many societies. In extremely high myopia, pathological myopia, which can cause visual loss, can occur. Pathological myopia is also accompanied by various visually perceivable symptoms on the retina, such as peripapillary atrophy. PAMELA is an automatic system for the detection of pathological myopia through the presence of peripapillary atrophy. In this paper, we describe...
Glaucoma is the second leading cause of permanent blindness worldwide. Glaucoma can be diagnosed through measurement of neuro-retinal optic cup-to-disc ratio (CDR). Correctly determining the optic disc region of interest (ROI) will produce a smaller initial image which takes much lesser time taken to process compared to the entire image. The earlier ROI localization in the ARGALI system used a grid...
Glaucoma is the second leading cause of blindness worldwide. The risk of glaucoma can be determined by calculating the cup to disc ratio in retinal fundus images. To accurately detect the optic cup, kinks or bends in small and medium vessels are important indicators of the cup boundary. In this paper, we present a method of detecting such vessels, through the extraction of patches and generation of...
Cataract is the leading cause of blindness and posterior subcapsular cataract (PSC) leads to significant visual impairment. An automatic approach for detecting PSC opacity in retro-illumination images is investigated. The features employed include intensity, edge, size and spatial location. The system was tested using 441 images. The automatic detection was compared with the human expert. The sensitivity...
The genome-wide association (GWA) study is the latest approach in the development of genetic studies and is renowned for its widespread success in identifying disease variants within the genome for various common diseases. It is a highly popular study amongst geneticists worldwide, evident from the numerous GWA studies conducted in laboratories all over the world. This paper introduces various GWA...
Objective quantification of lens images is essential for cataract assessment and treatment. In this paper, bottom-up and top-down strategies are combined to detect the lens contour from the slit-lamp images. The center of the lens is localized by horizontal and vertical intensity profile clustering and the lens contour is estimated by fitting an ellipse. A modified active shape model (ASM) is further...
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