Search results for: Zhiyuan Hu

Items from 1 to 20 out of 124 results

article

Thermal Computing with Mechanical Transistors (Adv. Funct. Mater. 25/2024)

Huyue Chen, Chao Song, Jiahao Wu, Bihui Zou, more

Advanced Functional Materials > 34 > 25 > n/a - n/a

Thermal Computing Traditional electronic computing frequently faces challenges such as elevated power usage, security risks, and vulnerability to harsh environmental factors, including extreme heat and radiation. In article number 2401244, Lei Shao, Jaehyung Ju, and co‐workers present a thermal computing approach using several mechanical transistors made from a Kirigami thermomechanical sensor coupled...

article

Thermal Computing with Mechanical Transistors

Huyue Chen, Chao Song, Jiahao Wu, Bihui Zou, more

Advanced Functional Materials > 34 > 25 > n/a - n/a

Mechanical computing has garnered significant interest as a supplement to traditional electronic computing, which often grapples with issues like high power consumption, security vulnerabilities, and susceptibility to extreme environmental conditions such as intense heat and radiation. Yet, most research in mechanical computing has been limited to the ad hoc design of simple logic gates and has not...

article

A Reactive Oxygen Species‐Responsive Targeted Nanoscavenger to Promote Mitophagy for the Treatment of Alzheimer's Disease

Zhimin Yang, Haoyuan Shi, Guoen Cai, Sujun Jiang, more

Small > 19 > 42 > n/a - n/a

Mitophagy modulators are proposed as potential therapeutic intervention that enhance neuronal health and brain homeostasis in Alzheimer's disease (AD). Nevertheless, the lack of specific mitophagy inducers, low efficacies, and the severe side effects of nonselective autophagy during AD treatment have hindered their application. In this study, the P@NB nanoscavenger is designed with a reactive‐oxygen‐species‐responsive...

article

A highly stable and low‐cost 12T radiation hardened SRAM cell design for aerospace application

Zhongyang Liu, Yuqiao Xie, Tao Xu, Qing Liu, more

International Journal of Circuit Theory and Applications > 51 > 8 > 3938 - 3948

In this paper, a highly stable and low‐cost 12T (HSLC12T) radiation hardened static‐random‐access‐memories (SRAM) cell is proposed in 55 nm CMOS technology. Based on polarity reversal design and read/write separation structure, the proposed HSLC12T cell can recover from any single event upsets (SEUs) induced at all its sensitive nodes and even single event double‐node‐upsets (SEDNUs) induced at its...

article

Scenario‐oriented repetitive project scheduling optimization

Zhiyuan Hu, Futian Wang, Yuanjie Tang

Computer‐Aided Civil and Infrastructure Engineering > 38 > 10 > 1239 - 1273

Research on project scheduling optimization is trending toward many‐objective optimization, in which the number of objectives exceeds three. However, existing studies usually only consider the necessary logical constraints, ignoring descriptions of practical scenarios and corresponding complex constraints, which limit the designed algorithms in problems with such scenarios and constraints. This study...

article

Fibroblast Activation Protein‐α Responsive Peptide Assembling Prodrug Nanoparticles for Remodeling the Immunosuppressive Microenvironment and Boosting Cancer Immunotherapy

Mengqi Sun, Shaobo Yao, Linyang Fan, Zhiguo Fang, more

Small > 18 > 9 > n/a - n/a

Checkpoint blockade immunotherapy has broad application prospects in the clinical treatment of malignant tumors. However, the low response rate of the checkpoint blockade is due to low tumor immunogenicity and immunosuppression within the tumor microenvironment. Herein, the authors design an amphiphilic bifunctional PD‐1/PD‐L1 peptide antagonist PCP, and co‐deliver doxorubicin (DOX) and R848 through...

article

Eating disorders treatment experiences and social support: Perspectives from service seekers in mainland China

Ruofan Ma, Manning Zhang, Jonathan M. Oakman, Jiping Wang, more

International Journal of Eating Disorders > 54 > 8 > 1537 - 1548

Objective This study explored treatment experiences and social support among individuals with eating disorders (EDs) in mainland China. Method Subscribers of a Chinese online social media platform (WeChat) focused on EDs were invited to complete a screening questionnaire that included the Eating Disorder Diagnostic Scale for the DSM‐5. Of the 116 questionnaire responses, 31 met inclusion criteria...

article

A robust overset assembly method for multiple overlapping bodies

Zhiyuan Hu, Guohua Xu, Yongjie Shi

International Journal for Numerical Methods in Fluids > 93 > 3 > 653 - 682

A robust overset assembly method allowing for multiple overlapping bodies is presented. This method extends the overset assembly method to deal with the interference between objects and prevents the failure of the search for donor cells due to the complex shape of the models. The donor cells are searched before identifying the boundary of the chimera interpolation. By selecting interpolation cells...

article

A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single‐Cell RNA Sequencing

Fanghao Shi, Fei Jia, Zewen Wei, Yan Ma, more

PROTEOMICS > 21 > 3-4 > n/a - n/a

Single‐cell RNA sequencing on circulating tumor cells (CTCs) proves useful to study mechanisms of tumor heterogeneity, metastasis, and drug resistance. Currently, single‐cell RNA sequencing of CTCs usually takes three prerequisite steps: enrichment of CTCs from whole blood, characterization of captured cells by immunostaining and microscopic imaging, and single‐cell isolation through micromanipulation...

article

Etiologic and treatment conceptualizations of disordered eating symptoms among mainland Chinese therapists

Ruofan Ma, Kevin P. Capobianco, NiCole T. Buchanan, Zhiyuan Hu, more

International Journal of Eating Disorders > 53 > 3 > 391 - 403

Objective Reports of disordered eating are increasing in mainland China; however, little is known regarding Chinese psychotherapists' conceptualizations of disordered eating symptomatology. This study explores Chinese psychotherapists' conceptualizations of binge eating (BE)/vomiting symptoms and treatment considerations. Method In‐depth, semi‐structured interviews were conducted with mainland...

article

Targeting Peptide‐Based Probes for Molecular Imaging and Diagnosis

Weizhi Wang, Zhiyuan Hu

Advanced Materials > 31 > 45 > n/a - n/a

A series of novel peptide‐based molecular probes for different biomarkers is highlighted herein. These probes can provide targeted recognition with high affinity, high specificity, high penetration, and rapid excretion ability. These sensitive peptides can achieve rapid and specific detection when they are conjugated with imaging moieties or are formed into nanoprobes, which can be adapted for in...

article

Experimental study on the emission characteristics of a non-road diesel engine equipped with different after-treatment devices

Yunhua Zhang, Diming Lou, Piqiang Tan, Zhiyuan Hu

Environmental Science and Pollution Research > 2019 > 26 > 26 > 26617- 26627

A comparative experiment was conducted based on a non-road diesel engine to investigate the effects of two after-treatment devices on the engine’s emission characteristics as well as their power and fuel consumption performances. The first after-treatment device is a combination of a diesel oxidation catalyst (DOC) and a catalytic diesel particulate filter (CDPF). The second device is a single CDPF-coated...

article

Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply

Yong Cong, Lei Ji, Yu‐Juan Gao, Fu‐Hua Liu, more

Angewandte Chemie > 131 > 14 > 4680 - 4685

In cancer treatment, the unsatisfactory solid‐tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self‐assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent an acid‐induced hydrophobicity increase with a narrow pH‐response range (from 7.4 to 6.5). In situ self‐assembly in the tumor microenvironment at appropriate molecular concentrations...

article

Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply

Yong Cong, Lei Ji, Yu‐Juan Gao, Fu‐Hua Liu, more

Angewandte Chemie International Edition > 58 > 14 > 4632 - 4637

article

Experimental study on the durability of biodiesel-powered engine equipped with a diesel oxidation catalyst and a selective catalytic reduction system

Yunhua Zhang, Diming Lou, Piqiang Tan, Zhiyuan Hu

Energy > 2018 > 159 > C > 1024-1034

This study aims to investigate the effect of durability on the regulated and unregulated emissions, as well as the power and fuel economy performance of a biodiesel-powered engine equipped with a diesel oxidation catalyst (DOC) and a selective catalytic reduction (SCR) system based on a 500-h durability test. Furthermore, a BET (Brunauer-Emmett-Teller) test was employed to analyze the specific surface...

article

Quantitative Proteomic Analysis of Cell Responses to Electroporation, a Classical Gene Delivery Approach

Minzhi Zhao, Deyao Zhao, Yan Ma, Zhiyuan Hu, more

PROTEOMICS > 18 > 16 > n/a - n/a

Electroporation, as an established nonviral technology for breaching cell membrane, has been accepted for the delivery of nucleic acids. Despite satisfactory delivery efficiencies have been achieved on multiple cell kinds by simply exhausting all possible electrical parameters, electroporation is still inefficient, or even invalid, for various kinds of cells. This is largely due to the lack of comprehensive...

article

A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer

Autumn J. McRee, Paul K. Marcom, Dominic T. Moore, William C. Zamboni, more

Clinical Breast Cancer > 2018 > 18 > 4 > 289-297

Buparlisib is an oral pan-class I phosphotidyinositol-3-kinase (PI3K) inhibitor. The present phase I study evaluated the safety, pharmacokinetics, and efficacy of buparlisib with capecitabine in patients with metastatic breast cancer.Patients received buparlisib once daily (range, 50 to 100 mg) for 3 weeks with capecitabine twice daily (range, 1000 to 1250 mg/m²) for 2 weeks with a 1-week break. Dose...

article

Molecular Cancer Imaging in the Second Near‐Infrared Window Using a Renal‐Excreted NIR‐II Fluorophore‐Peptide Probe

Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, more

Advanced Materials > 30 > 22 > n/a - n/a

In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody‐modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near‐infrared window...

article

Evolution of Non-metallic Inclusions and Precipitates in Oriented Silicon Steel

Yan Luo, Wen Yang, Qiang Ren, Zhiyuan Hu, more

Metallurgical and Materials Transactions B > 2018 > 49 > 3 > 926-932

The evolution of inclusions in oriented silicon steel during the manufacturing process was carried out by chemical composition analysis, non-aqueous electrolytic corrosion, and thermodynamic calculation. The morphology, composition, and size of inclusions were analyzed introducing field emission scanning electron microscope. The oxides were mainly formed during the secondary refining, and the nitrides,...

article

Frequency of breast cancer subtypes among African American women in the AMBER consortium

Emma H. Allott, Joseph Geradts, Stephanie M. Cohen, Thaer Khoury, more

Breast Cancer Research > 2018 > 20 > 1 > 1-9

Background Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional markers. However, automated biomarker scoring and classification schemes have not been standardized. The aim of this study was to optimize tumor classification using automated methods...

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INFONA - science communication portal

Search results for: Zhiyuan Hu

Thermal Computing with Mechanical Transistors (Adv. Funct. Mater. 25/2024)

Thermal Computing with Mechanical Transistors

A Reactive Oxygen Species‐Responsive Targeted Nanoscavenger to Promote Mitophagy for the Treatment of Alzheimer's Disease

A highly stable and low‐cost 12T radiation hardened SRAM cell design for aerospace application

Scenario‐oriented repetitive project scheduling optimization

Fibroblast Activation Protein‐α Responsive Peptide Assembling Prodrug Nanoparticles for Remodeling the Immunosuppressive Microenvironment and Boosting Cancer Immunotherapy

Eating disorders treatment experiences and social support: Perspectives from service seekers in mainland China

A robust overset assembly method for multiple overlapping bodies

A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single‐Cell RNA Sequencing

Etiologic and treatment conceptualizations of disordered eating symptoms among mainland Chinese therapists

Targeting Peptide‐Based Probes for Molecular Imaging and Diagnosis

Experimental study on the emission characteristics of a non-road diesel engine equipped with different after-treatment devices

Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply

Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply

Experimental study on the durability of biodiesel-powered engine equipped with a diesel oxidation catalyst and a selective catalytic reduction system

Quantitative Proteomic Analysis of Cell Responses to Electroporation, a Classical Gene Delivery Approach

A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer

Molecular Cancer Imaging in the Second Near‐Infrared Window Using a Renal‐Excreted NIR‐II Fluorophore‐Peptide Probe

Evolution of Non-metallic Inclusions and Precipitates in Oriented Silicon Steel

Frequency of breast cancer subtypes among African American women in the AMBER consortium

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