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Bipolar disorder is a chronic psychiatric condition during which patients experience mood swings among depression, hypomania or mania, mixed state (depression-hypomania) and euthymia, i.e., good affective balance. Nowadays, an objective characterization of the temporal trends of the disease as a response to the pharmacological treatment through physiological signatures, especially during severe episodes,...
Complexity measures from Multiscale Entropy (MSE) analysis of cardiovascular variability may provide potential biomarkers of pathological mental states such as major depression. To this extent, in this study we investigate whether complexity of Heart Rate Variability (HRV) is also affected in mental disorders such as bipolar disorders (BD). As part of the European project PSYCHE, eight BD patients...
The objective quantification of psychological traits through Autonomic Nervous System (ANS) biomarkers is of large interest for the clinical and bioengineering scientific communities. Standard procedures, in fact, rely only on subjective scores from interviews and questionnaires. Here we show that monovariate and multivariate multiscale entropy measures are able to characterize the dimension regulating...
This study reports on a Multiscale Entropy (MSE) analysis on Heart Rate Variability (HRV) series gathered from eight patients with pathological mental states. Specifically, we found that an HRV complexity modulation exists in bipolar patients who exhibit mood states among depression, hypoma-nia, and euthymia, i.e., good affective balance. Two different methodologies for the choice of the sample entropy...
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