Search results for: Jie Liang

Items from 1 to 20 out of 912 results

article

Structurally Divergent Synthesis of Azetidines, 5,6‐Dihydro‐1,3‐oxazines and 2,3‐Dihydro‐1,4‐oxazines through Palladium‐Catalyzed Tandem Allylic Substitution Reaction

Ru‐Fang Meng, Yu‐Juan Kong, Xiao‐Yan Wu, Huan Zhang, more

Chinese Journal of Chemistry > 42 > 22 > 2773 - 2778

A regiodivergent synthesis of azetidines, 5,6‐dihydro‐1,3‐oxazines and 2,3‐dihydro‐1,4‐oxazines has been achieved through palladium‐catalyzed tandem allylic substitution reaction. This protocol provides a variety of heterocycles in satisfactory yields with good to excellent regioselectivities under mild reaction conditions.

article

Functionalized Binders Boost High‐Capacity Anode Materials

Shaowen Dong, Li Wang, Xiaolong Huang, Jie Liang, more

Advanced Functional Materials > 34 > 41 > n/a - n/a

The burgeoning field of energy storage battery innovation has sparked a relentless pursuit of high‐capacity anode materials to meet the escalating demand for improved energy density. Typically, these materials for batteries experience significant volume changes during cycles, which severely test the structural integrity and lifespan of electrode configurations. High‐performance binders have emerged...

article

Delivery Systems Developed for Treatment Combinations to Improve Adoptive Cell Therapy

Fengfei Xu, Qiankun Ni, Ningqiang Gong, Bozhang Xia, more

Advanced Materials > 36 > 40 > n/a - n/a

Adoptive cell therapy (ACT) has shown great success in the clinic for treating hematologic malignancies. However, solid tumor treatment with ACT monotherapy is still challenging, owing to insufficient expansion and rapid exhaustion of adoptive cells, tumor antigen downregulation/loss, and dense tumor extracellular matrix. Delivery strategies for combination cell therapy have great potential to overcome...

article

Elimination of Intragrain Defect to Enhance the Performance of FAPbI₃ Perovskite Solar Cells by Ionic Liquid

Yi‐Xian Wan, Hong‐Qiang Du, Yang Jiang, Rui Zhi, more

Small > 20 > 34 > n/a - n/a

Ionic liquids have been widely used to improve the efficiency and stability of perovskite solar cells (PSCs), and are generally believed to passivate defects on the grain boundaries of perovskites. However, few studies have focused on the relevant effects of ionic liquids on intragrain defects in perovskites which have been shown to be critical for the performance of PSCs. In this work, the effect...

article

Spectrum–effect relationship between HPLC fingerprint and hypoglycemic of litchi leaves (Litchi chinensis Sonn) in vitro

Yanli Liang, Jingjing Xie, Dongfang Huang, Yupin Cao, more

Biomedical Chromatography > 38 > 9 > n/a - n/a

Litchi chinensis Sonn (Litchi) has been listed in the Chinese Pharmacopeia, and is an economically and medicinally valuable species within the family Sapindaceae. However, the material basis of its pharmacological action and the pharmacodynamic substances associated with its hypoglycemic effect are still unclear. The predominant objective of this study was to establish the fingerprint profile of litchi...

article

A facile Immunoregulatory Constructional Design by Proanthocyanidin Optimizing Directional Chitosan Microchannel

Xing Li, Yuxiang Wang, Chengkun Zhao, Lei Tong, more

Small > 20 > 31 > n/a - n/a

Improving the interconnected structure and bioregulatory function of natural chitosan is beneficial for optimizing its performance in bone regeneration. Here, a facile immunoregulatory constructional design is proposed for developing instructive chitosan by directional freezing and alkaline salting out. The molecular dynamics simulation confirmed the assembly kinetics and structural features of various...

article

Tungstate Intercalated NiFe Layered Double Hydroxide Enables Long‐Term Alkaline Seawater Oxidation

Hefeng Wang, Zixiao Li, Shaohuan Hong, Chaoxin Yang, more

Small > 20 > 28 > n/a - n/a

Renewable electricity‐driven seawater splitting presents a green, effective, and promising strategy for building hydrogen (H₂)‐based energy systems (e.g., storing wind power as H₂), especially in many coastal cities. The abundance of Cl⁻ in seawater, however, will cause severe corrosion of anode catalyst during the seawater electrolysis, and thus affect the long‐term stability of the catalyst. Herein,...

article

P‐10.11: Digital Microfluidics Chip for Sweat Detection Based on Dielectric Wetting

Zhiwei Zhang, Yi Li, Jie Liang, Lei Zhang, more

SID Symposium Digest of Technical Papers > 55 > S1 > 1276 - 1278

Digital microfluidics (DMF) is a technique for actively dispensing and manipulating discrete microdroplets on hydrophobic surfaces. DMF devices based on electrowetting on medium (EWOD) effect are widely used due to their advantages of fast response speed, simple system and high accuracy. Microfluidics is important for sweat sensing because it minimizes sweat pollution and evaporation of sweat on the...

article

P‐10.12: Glucose Sensor Design based on Microneedle Integrated EG‐TFT

Junfeng Zhao, Yi Li, Jie Liang, Lei Zhang, more

SID Symposium Digest of Technical Papers > 55 > S1 > 1279 - 1281

We have designed an extended‐gate thin‐film transistor (EG‐TFT) enzyme sensor for the detection of glucose. The device is composed of a surface‐modified microneedle working electrode incorporating glucose oxidase (GOx) and Prussian blue (PB) alongside a reference electrode. The electrodes are connected to the gate and source of a transistor, respectively. The TFT structure of the device has a bottom...

article

P‐10.10: Wearable Transdermal Drug Delivery Devices based on Piezoelectric Micropumps Integrated with Microneedles Array

Wei Sha, Yi Li, Jie Liang, Lei Zhang, more

SID Symposium Digest of Technical Papers > 55 > S1 > 1271 - 1275

Transdermal drug delivery refers to a drug delivery route that delivers drugs through the skin to produce local or systemic therapeutic effects. In this work, we propose a parallel valveless piezoelectric micropump integrated with hollow microneedle array, which can be used in flexible wearable transdermal drug delivery systems. The device consists of two valveless piezoelectric micropump, a hollow...

article

26‐1: A Wearable Glucose Sensor Integrated with Hollow Microneedles and Reverse Iontophoresis Extraction^†

Lulu Liu, Yi Li, Jie Liang, Lei Zhang, more

SID Symposium Digest of Technical Papers > 55 > S1 > 227 - 230

Reverse iontophoresis (RI) technology has the advantages of wearable and painless in the field of continuous glucose monitoring. However, there are still challenges in optimizing the extraction throughput and consistency of RI. Here, we study an extraction and detection system based on microneedles, which integrates hollow microneedles and constant current adjustable circuits to achieve efficient...

article

Prioritizing conservation efforts based on future habitat availability and accessibility under climate change

Jie Liang, Wanting Wang, Qing Cai, Xin Li, more

Conservation Biology > 38 > 3 > n/a - n/a

The potential for species to shift their ranges to avoid extinction is contingent on the future availability and accessibility of habitats with analogous climates. To develop conservation strategies, many previous researchers used a single method that considered individual factors; a few combined 2 factors. Primarily, these studies focused on identifying climate refugia or climatically connected and...

article

Nanomedicine for T‐Cell Mediated Immunotherapy (Adv. Mater. 22/2024)

Fangzhou Li, Jiang Ouyang, Zuqin Chen, Ziran Zhou, more

Advanced Materials > 36 > 22 > n/a - n/a

Nanomedicine Nanomedicines, with their diverse, flexible, and intelligent features, can enhance T cell‐based therapy for various diseases. The article number 2301770 by Weisheng Guo, Xing‐Jie Liang, and co‐workers focuses on T‐cell immunotherapy and how nanotechnology can improve its efficacy and safety, provides a deeper understanding of the mechanisms and challenges involved in using nanomedicines...

article

Cell‐Reprogramming‐Inspired Dynamically Responsive Hydrogel Boosts the Induction of Pluripotency via Phase‐Separated Biomolecular Condensates

Fei Zhu, Na Yan, Xukun Lu, Junchao Xu, more

Advanced Materials > 36 > 22 > n/a - n/a

Induced pluripotent stem cells (iPSCs) have wide applications in disease modeling, personalized medicine, and tissue engineering. The generation of iPSCs from somatic cells via transcriptional‐factor‐ or chemical molecule‐based approaches are time‐consuming and inefficient. Here, a cell‐reprogramming‐inspired dynamically responsive hydrogel is fabricated via a synthetic‐biology‐based strategy. Human...

article

Nanomedicine for T‐Cell Mediated Immunotherapy

Fangzhou Li, Jiang Ouyang, Zuqin Chen, Ziran Zhou, more

Advanced Materials > 36 > 22 > n/a - n/a

T‐cell immunotherapy offers outstanding advantages in the treatment of various diseases, and with the selection of appropriate targets, efficient disease treatment can be achieved. T‐cell immunotherapy has made great progress, but clinical results show that only a small proportion of patients can benefit from T‐cell immunotherapy. The extensive mechanistic work outlines a blueprint for using T cells...

article

Blood–Brain Barrier‐Penetrating and Lesion‐Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy

Lu Tang, Yue Yin, Hening Liu, Mengliang Zhu, more

Advanced Materials > 36 > 21 > n/a - n/a

Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due to its complicated pathophysiological features, current treatment options after ischemic stroke attack remains unsatisfactory. Insufficient drug delivery to ischemic lesions impeded by the blood–brain barrier (BBB) largely limits the therapeutic efficacy of most anti‐stroke agents. Herein, inspired...

article

Engineered Microchannel Scaffolds with Instructive Niches Reinforce Endogenous Bone Regeneration by Regulating CSF‐1/CSF‐1R Pathway

Xing Li, Yaling Cheng, Peiyang Gu, Chengkun Zhao, more

Advanced Materials > 36 > 19 > n/a - n/a

Structural and physiological cues provide guidance for the directional migration and spatial organization of endogenous cells. Here, a microchannel scaffold with instructive niches is developed using a circumferential freeze‐casting technique with an alkaline salting‐out strategy. Thereinto, polydopamine‐coated nano‐hydroxyapatite is employed as a functional inorganic linker to participate in the...

article

Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy

Manyu Chen, Yan Lu, Yuhan Liu, Quanying Liu, more

Advanced Materials > 36 > 16 > n/a - n/a

Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation of FGF18‐based protein drugs is hindered by their short half‐life, low delivery efficiency and the need for repeated articular injections. This study proposes a CRISPR/Cas9‐based approach to effectively activate the FGF18 gene of OA...

article

Carbon fluxes of China's coastal wetlands and impacts of reclamation and restoration

Weizhi Lu, Jingfeng Xiao, Haiqiang Gao, Qingyu Jia, more

Global Change Biology > 30 > 4 > n/a - n/a

Coastal wetlands play an important role in regulating atmospheric carbon dioxide (CO₂) concentrations and contribute significantly to climate change mitigation. However, climate change, reclamation, and restoration have been causing substantial changes in coastal wetland areas and carbon exchange in China during recent decades. Here we compiled a carbon flux database consisting of 15 coastal wetland...

article

Echinacoside Exerts Antihepatic Fibrosis Effects in High‐Fat Mice Model by Modulating the ACVR2A‐Smad Pathway

Jie Liang, Ting Chen, Honglei Xu, Tingfang Wang, more

Molecular Nutrition & Food Research > 68 > 6 > n/a - n/a

Scope Nonalcoholic steatohepatitis (NASH) is an increasingly common chronic liver disease in which hepatic fibrosis is the major pathological change. The transforming growth factor β (TGF‐β)/mall mothers against decapentaplegic (Smad) signaling is the main effector of fibrosis. Although the antifibrotic effect of echinacoside (Ech) on the liver has been indicated previously, the cellular and molecular...

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INFONA - science communication portal

Search results for: Jie Liang

Structurally Divergent Synthesis of Azetidines, 5,6‐Dihydro‐1,3‐oxazines and 2,3‐Dihydro‐1,4‐oxazines through Palladium‐Catalyzed Tandem Allylic Substitution Reaction

Functionalized Binders Boost High‐Capacity Anode Materials

Delivery Systems Developed for Treatment Combinations to Improve Adoptive Cell Therapy

Elimination of Intragrain Defect to Enhance the Performance of FAPbI₃ Perovskite Solar Cells by Ionic Liquid

Spectrum–effect relationship between HPLC fingerprint and hypoglycemic of litchi leaves (Litchi chinensis Sonn) in vitro

A facile Immunoregulatory Constructional Design by Proanthocyanidin Optimizing Directional Chitosan Microchannel

Tungstate Intercalated NiFe Layered Double Hydroxide Enables Long‐Term Alkaline Seawater Oxidation

P‐10.11: Digital Microfluidics Chip for Sweat Detection Based on Dielectric Wetting

P‐10.12: Glucose Sensor Design based on Microneedle Integrated EG‐TFT

P‐10.10: Wearable Transdermal Drug Delivery Devices based on Piezoelectric Micropumps Integrated with Microneedles Array

26‐1: A Wearable Glucose Sensor Integrated with Hollow Microneedles and Reverse Iontophoresis Extraction^†

Prioritizing conservation efforts based on future habitat availability and accessibility under climate change

Nanomedicine for T‐Cell Mediated Immunotherapy (Adv. Mater. 22/2024)

Cell‐Reprogramming‐Inspired Dynamically Responsive Hydrogel Boosts the Induction of Pluripotency via Phase‐Separated Biomolecular Condensates

Nanomedicine for T‐Cell Mediated Immunotherapy

Blood–Brain Barrier‐Penetrating and Lesion‐Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy

Engineered Microchannel Scaffolds with Instructive Niches Reinforce Endogenous Bone Regeneration by Regulating CSF‐1/CSF‐1R Pathway

Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy

Carbon fluxes of China's coastal wetlands and impacts of reclamation and restoration

Echinacoside Exerts Antihepatic Fibrosis Effects in High‐Fat Mice Model by Modulating the ACVR2A‐Smad Pathway

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