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Previously, we showed an inverse correlation between HSP27 serum levels and experimental atherogenesis in ApoE −/− mice that over-express HSP27 and speculated that the apparent binding of HSP27 to scavenger receptor-A (SR-A) was of mechanistic importance in attenuating foam cell formation. However, the nature and importance of the interplay between HSP27 and SR-A in atheroprotection remained...
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