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Cigarette smoking is the top environmental risk factor for lung cancer. Nicotine, the addictive component of cigarettes, induces lung cancer cell proliferation, invasion and migration via the activation of nicotinic acetylcholine receptors (nAChRs). Genome-wide association studies (GWAS) show that CHRNA5 gene encoding α5-nAChR is especially relevant to lung cancer. However, the mechanism of this subunit...
Nicotine, the chemical compound which causes cigarette addiction, could be responsible for some lung cancers. Evidence for genetic influence on smoking behavior and nicotine dependence has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Recently, the locus containing two genes encoding nicotine...
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