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Few investigations have been published demonstrating the in vivo contrast characteristics of phase-change perfluorocarbon droplets. In this study, we examine the properties of low boiling point nanoscale droplets compared to microbubbles with respect to image enhancement and circulation time. To accomplish this, we develop a custom pulse sequence to vaporize and image droplets using the Verasonics...
Most gas-filled ultrasound contrast agents are produced range of several microns in diameter, which limits them to flow within intravascular space. One mechanism proposed to produce extravascular imaging agents is acoustic droplet vaporization. Liquid perfluorocarbon droplets can be manufactured in the sub-micron range and can then passively diffuse through leaky tumor vasculature. It is hypothesized...
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