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In recent years, small‐molecule inhibitors targeting the autotaxin (ATX)/lysophosphatidic acid axis gradually brought excellent disease management benefits. Herein, a series of imidazo[1,2‐a]pyridine compounds (1–11) were designed as ATX inhibitors through a hybrid strategy by combining the imidazo[1,2‐a]pyridine skeleton in GLPG1690 and the benzyl carbamate moiety in PF‐8380. As indicated by FS‐3‐based...