The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
We developed an active virus filter (AVF) that was able to virus enrichment and distribution for single virus manipulation by using the insulator based dielectrophoresis (iDEP). The design of constricted flow channel enabled the microfluidic chip to produce iDEP force. We utilized maskless photolithography to achieve the precise 3D gray-scale exposure for constricted flow channel. When we applied...
In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedom-in the X- and Y-directions. The MMT works on the principle of noncontact...
This paper presents innovative driving method for the magnetically driven microtool (MMT) which is actuated in a microfluidic chip by permanent magnets on the XY stage. A piezoelectric ceramic is applied to induce ultrasonic vibration to the microfluidic chip and the high-frequency vibration reduces the effective friction on the MMT significantly. As a result, we achieved 1.1 micrometer positioning...
This paper presents a novel method of three-dimensional fabrication using Mask-less exposure equipment and a three dimensional microfluidic application for the cell manipulation. The grayscale data can directly control the height of the photoresist to be exposed without using any mask. Three-dimensional microchannel was successfully fabricated simply by using the low cost exposure system with the...
In this paper, we discuss a development of control and sensing platform for an on-chip single cell evaluation by magnetically driven microtool (MMT). The design and fabrication of the MMT is shown. Through the basic experiments, the advantage of the proposed platform, the performance of the position control (positioning accuracy: 30 μm), and the force sensing (sensing accuracy: 100 μN) of the MMT...
In this report, we will present a novel liposome handling method on microfluidic channel. For the quantitative analysis of individual giant liposomes, a microfluidic device with multi-pillar was designed. Liposomes suspension from neutral phospholipids prepared by natural swelling method was introduced into the separation device. As a result, giant liposomes are safely trapped in the microscope view...
Nanomanipulation of a single influenza virus in a microfluidic chip for biomedical innovation was developed. We employed Robot on a Chip (RoC) to achieve stable manipulation of nano-scale biomaterials such as virus (size is about 100 nm). The microfluidic chip has independent virus chamber and cell chamber to make quantitative analysis such as single virus infection to a specific cell. Gel-microtool...
Technologies to develop scaffolds with controlled pore layout and porosity have great significance in tissue engineering. As one method of scaffold fabrication, porogen leaching has been commonly used to control pore size, pore structure and porosity in the scaffold. In this paper, we describe a novel approach to fabricate 2D and 3D porous biodegradable scaffolds made of poly(L-lactide-co-epsiv-caprolactone)...
In this study, we tried to create a polydimethyl -siloxane (PDMS) scaffold with controlled pore configurations to investigate the proliferation and differentiation of the cells seeded 3-dimensionally. The three-dimensional scaffold was designed to investigate the effect of mechanical stress to the cells by utilizing the intrinsic elasticity of the PDMS. We used a combination of casting mold and lamination...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.